Jefferson City, Missouri is the capital of Missouri and is located in the center of Missouri. The median price for a home for sale in Jefferson City, MO is $137,586. This is much lower than the country average. Jefferson City is a great place to find affordable housing in a central location to all that Missouri has to offer. Jefferson City real estate has single-family homes, condos, multi-family, commercial, land and more available. When entering Jefferson City from the North you are enveloped by the beauty of the capital and the fierce Missouri River. The capital is perched above the river in perfect view when crossing over the bridge.